There are a range of potential causes of physical discomfort following brain injury.  Due to cognitive and/or communication impairments, patients may be limited in their ability to understand their symptoms and/or effectively seek help. Therefore, physical symptoms may manifest as frustration and/or distress. Even without physical causes of discomfort, the patient may present with anxiety and/or agitation associated with limited insight into their impairments (especially if these impairments lead to others imposing restrictions on them).  Contributing factors to distress may include the following: